Growth and Growth Hormone Secretion Following Cranial and Craniospinal Irradiation in Children with Malignant Disease
نویسنده
چکیده
grow. The Bristol paediatric oncology and paediatric endocrinology services have collaborated to investigate the effects of chemotherapy and craniospinal irradiation on the longitudinal growth of survivors. Figure 1 shows the longitudinal height-attained growth chart of a child who grew poorly following treatment for a medulloblastoma. Our experience, and that of others, is that children treated for brain tumours, head and neck tumours and some leukaemic children are at risk of subsequent growth impairment (1,2,3). Some of these children can be shown in conventional pharmacological stimulation tests to become growth hormone (GH) deficient (1,4). Others grow poorly despite having apparently normal GH reserves. The object of our research was to investigate this phenomenon further. RADIOTHERAPY OR CHEMOTHERAPY? ,
منابع مشابه
Effect of treatment of malignant disease on growth in children.
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